Pioneering Custom Disease Models to Accelerate Drug & Medical Device Development
At HT Biosciences, we specialize in designing and validating 200+ standardized and custom animal disease models across species including non-human primates (NHPs), pigs, dogs, rabbits, and rodents. Our platform integrates surgical, chemical, genetic, and dietary induction methods to replicate human disease pathophysiology, enabling precise efficacy and safety evaluations for pharmaceuticals, biologics, and medical devices.
Core Disease Model Libraries
|
Disease System |
Key Models |
|
Cardiovascular |
Myocardial Infarction (Pig) Atrial Fibrillation (Rabbit) Atherosclerosis (ApoE-/- Mice) Heart Failure (Rat) |
|
Neurological |
Alzheimer’s (Transgenic Mice) Parkinson’s (MPTP-Induced NHP) Stroke (MCAO Rat) Spinal Cord Injury (Rabbit) |
|
Oncology |
Xenograft Tumors (Mice) VX2 Liver Cancer (Rabbit) PDX Models (Mice) Glioblastoma (Pig) |
|
Metabolic |
Type 1/2 Diabetes (Mice/Rats/Pigs) NAFLD (Methionine-Choline Deficient Diet Mice) Obesity (DIO Mice) |
|
Respiratory |
Asthma (OVA-Sensitized Rats) COPD (Cigarette Smoke Exposure Mice) Pulmonary Fibrosis (Bleomycin-Induced Mice) |
|
Orthopedic |
Osteoarthritis (Surgical Rat) Osteoporosis (OVX Rats) Bone Defect (Rabbit Tibia) |
|
Dermatological |
Diabetic Ulcer (Rat) Psoriasis (IMQ-Induced Mice) Burn Injury (Pig) |
|
Renal |
Acute Kidney Injury (Cisplatin-Induced Mice) Chronic Kidney Disease (5/6 Nephrectomy Rat) |
- By Therapeutic Area
- By Induction Method
- Surgical Models: Coronary ligation (MI), spinal cord compression, organ transplantation.
- Chemical/Dietary Models: STZ-induced diabetes, high-fat diet obesity, CCl4 liver fibrosis.
- Genetic Models: Transgenic Alzheimer’s mice, ApoE-/- atherosclerosis models.
- Infection/Immune Models: Collagen-induced arthritis, LPS-induced sepsis.